Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1)
نویسندگان
چکیده
منابع مشابه
Voltage-gated Proton “Channels”
A battle is raging over the molecular identity of the voltage-gated, H -selective conductance that has been recorded in activated and/or depolarized phagocytes. Having stepped out of this arena, we feel uncommitted to any particular viewpoint and hope to be able to provide below an unbiased opinion of what we feel has been established unambiguously, and what requires additional confirmation bef...
متن کاملPhilosophy of voltage-gated proton channels.
In this review, voltage-gated proton channels are considered from a mainly teleological perspective. Why do proton channels exist? What good are they? Why did they go to such lengths to develop several unique hallmark properties such as extreme selectivity and ΔpH-dependent gating? Why is their current so minuscule? How do they manage to be so selective? What is the basis for our belief that th...
متن کاملPharmacology of voltage-gated proton channels.
Voltage-gated proton channels are highly proton selective ion channels that are present in many cells. Although their unitary conductance is 1000 times smaller than that of most ion channels, detection of single-channel currents supports their identification as channels rather than carriers. Proton channels are gated by membrane depolarization, but their absolute voltage dependence is also stro...
متن کاملDiversity of voltage gated proton channels.
Voltage gated proton channels were first discovered in snail neurons and recently have been found in many mammalian cells. As their name suggests, H+ channels are sensitive to voltage, with an open probability that increases with membrane depolarization. Many properties that are shared by voltage-gated proton channels make them unique among ion channels. They show high selectivity for protons, ...
متن کاملVoltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
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ژورنال
عنوان ژورنال: Channels
سال: 2017
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2017.1385684